If you are going to use ToscaWidgets in a Grok application, you can as long as your Grok app is a WSGI app. Grok has a way of doing this here
Then, you need to modify your grok.ini to include the toscawidgets middleware:
add:
[filter:tosca]
use=egg:toscawidgets#middleware
default_view=genshi
modify:
[pipeline:main]
pipeline = egg:Paste#cgitb
egg:Paste#httpexceptions
suppressZopeErrorHandling
tosca
bbb